10/16/2003
Living Long
Last week I mentioned the 2003 Nobel Prize in medicine awarded to Paul Lauterbur and Sir Peter Mansfield for their contributions toward the invention and development of magnetic resonance imaging, MRI. It turns out that this year’s Nobel awards are generating rather negative reactions in some quarters. For example, the Nobel Peace Prize to an Iranian woman has prompted protests from Iranian hard-liners. Now I find in a Reuters dispatch posted on AOL a violent reaction to the prize in medicine by Dr. Raymond Damadian.
I mentioned Damadian in the column last week as one of those who performed the first MRI on a human patient. I haven’t seen either ad but it seems that Damadian took out full page ads in both the New York Times and the Washington Post describing the prize as “The Shameful Wrong That Must be Righted”. Estimates in the Reuters dispatch indicate a total cost of these two ads in the ballpark of $200,000! Damadian obviously feels strongly about the subject. He apparently has a patent on MRI, based on his discovery in 1970 that cancerous tissue can be differentiated from normal tissue using nuclear magnetic resonance, the basic technique used in MRI. He feels that he should have shared in the prize and that the Nobel committee deliberately excluded him. I’m not touching this controversy but felt I should call it to your attention.
Wherever the proper credit should go, the MRI remains a valuable tool that can save or prolong lives by detecting problems that need attention. Speaking of living long, you may have read of the recent passing of Elena Slough, a resident of our state of New Jersey. Slough’s daughter had died just three days earlier at the age of 90. As you might expect from the age of the daughter, Elena must have lived a long life herself. In fact, she was either 114 0r 115 years old and was the nation’s oldest living American.
Wilbur Snapp of Florida didn’t live as long; he was only 83 when he died last month. Snapp was the organist at a minor league baseball park when he may have been the only organist ever to be ejected from a game by the umpire. After a call by the ump that Snapp thought to be erroneous, he launched onto the tune “Three Blind Mice”. The ump responded by giving him the thumb! I found this item in K. M. Reese’s column in the September 22 issue of Chemical and Engineering News (C&EN).
In the October 6 issue of C&EN, Reese followed up on a subject about which I had written not too long ago. You may recall the problem that a Japanese railway had with collisions with deer crossing the tracks. One method that seemed to shoo away the deer was to hang pieces of white Styrofoam along the tracks, the rationale being that deer dislike the color white. It was thought that this was the reason hunters avoid wearing white. However, Reese received a letter from a Pennsylvania hunter, Edward Felon, who demurs. Ed says that his father taught him to avoid wearing white but for a different reason, self-preservation. Dad told Ed that, when a whitetail deer runs, its tail points up and waves. If you wear white, other hunters seeing the white in the brush might think you were a deer and shoot! Ed suggests the Japanese need to do more controlled experiments with Styrofoam of different colors to make sure it’s not just the Styrofoam scaring away the deer.
This example of how a hunter might prolong his life fits into the general theme of living long or put another way, “Staying Alive”, the title of an article by Karen Wright in the November 2003 issue of Discover magazine. The article deals with the increasing numbers of centenarians in the U.S. and other industrialized countries and the outlook for the future. In 1950 there were some 2,300 people in the U.S. that were 100 years old or older. Today, there are over 40,000 centenarians and Willard Scott is having trouble keeping up with those Smucker’s jars.
That the average lifespan has increased substantially over the past century or two is well known. However, James Vaupel, of the Max Planck Institute for Demographic Research in Germany, has come up with a finding that has surprised researchers in the demographic field. Vaupel found that in many industrialized countries the average lifespan has shown a remarkably linear increase of more than two years each decade since 1840. If this linear growth in lifespan is extrapolated out to the year 2150, the average lifespan will be 122.5 years! The feasibility of living to 122 has been demonstrated by the oldest documented human being, Louise Calment of France, who died several years ago at that age.
With an average age of 122 years, there should be some outliers who are 150! That means that someone living today will still be around in the year 2150. I don’t know about you but I’m just a tad skeptical about this conclusion, which was voiced by gerontologist Steve Austad of the University of Idaho. Equally skeptical was Austad’s friend Jay Olshansky, a biodemographer at the University of Illinois. When Olshansky called Austad to question whether he had been properly quoted, Austad replied that he was so confident of his statement that he would be willing to bet on it.
The two agreed to a most unusual bet. They each would place $150 into an investment fund and add $10 to the pot each year. They figure that by 2150 the fund should be worth a cool $500 million! In 2150, the amount in the fund would be distributed among the relatives of the winner of the bet, who will be long gone by that time. I don’t know how prolific the Austad and the Olshansky progeny will be but I foresee quite a legal problem trying to identify all the heirs to this half a billion after 147 more years have passed!
What is the basis for Austad’s optimism? He points to various animal and insect studies, some of which we’ve touched upon in earlier columns. For example, he cites the finding that a single mutation in a roundworm can lead to a lifespan of six times the normal roundworm lifespan. If I apply that factor to the 122 years of Madame Calment, it would come very close to the Biblical age claimed for Methuselah. There are all kinds of experiments like this, such as the one by Michael Rose of the University of California at Irvine. He culled and fertilized eggs from only older female fruit flies. After many generations he had managed to double the lifespan of his flies!
Closer to our own species, Austad found something interesting in the case of the opossum during a stay in Venezuela. The opossums there have to breed in a hurry because they’re the prey for numerous predators ranging from parasites to cougars to owls, etc. The opossum is slow and not well equipped to fend off these predators. As a result, they last for one breeding season, if they make it to that point. From the evolutionary standpoint, it doesn’t make much sense for nature to endow them with a great immune system to fend off diseases since they’ll be eaten or otherwise killed off early anyway. Better to breed fast and produce a lot of kids quickly.
To test his idea that a safe environment promotes different behavior, Austad found a bunch of opossums that had been isolated for thousands of years on an island with essentially no predators. Sure enough, these possums bred more slowly, had the luxury of two breeding seasons and lived on average 25 percent longer than their Venezuelan counterparts. The oldest possums lived 50 percent longer. Austad postulates that safety of the environment explains why we humans live twice as long as captive chimpanzees, which share 99 percent of our genes. By making things comfortable for ourselves, his theory is that a longer lifespan eventually gets encoded in our DNA.
At age 75, I would be quite satisfied just to make it into my 80s. I’ll leave it to any very young readers to follow whether or not Austad wins his bet!
Allen F. Bortrum
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