10/04/2006
Messing with the Brain
Two weeks ago, in a discussion of refrigerants and the ozone layer, I may have left an overly optimistic impression of the state of progress in restoring the ozone layer. When I said that we had turned the corner, I didn’t mean to imply that everything was back to normal, especially in view of a Reuters news item dated October 2 posted on AOL News. The article says that the European Space Agency has found that the hole in the ozone layer over Antarctica hit a record size this year. At some 11 million square miles, the Antarctic ozone hole is expected to recur for decades at about the same size before finally returning to normal by about 2065. However, according to the World Meteorological Organization, the ozone layer over us in North America will be back at pre-1980 levels by about 2049. There is light at the end of the tunnel.
Now let’s revisit another topic in an earlier column (10/10/2002). The topic was the brain and the amazing performance of savants in such varied fields as mathematics, music, memorization and painting. A savant may, for example, memorize a whole book word for word after a single reading but not comprehend the meaning. It’s as though the savant copies each word in the brain but makes no attempt to put the words in context. In some cases, there has been damage to a specific region of the brain known to be involved in analysis and putting information into proper context.
Some researchers, notably Allan Snyder and colleagues at the Australian National University and other Australian universities, concluded that such brain-damaged savants are unencumbered by the need to expend energy sorting out the meaning of the letters, numbers, words or musical notes they take into their brains. The Australians wondered whether normal individuals couldn’t duplicate some of the prowess of the savant if the same part of the brain was temporarily deactivated or disabled. The part of the brain the researchers targeted is called the left anterior temporal lobe.
As I mentioned back in 2002, the Australian researchers decided to deliberately interfere with the functioning of that part of the brain through the use of magnetic pulses, a procedure termed transcranial magnetic stimulation (TMS). Sure enough, the researchers found that when they turned on the TMS machine, certain subjects performed better in certain artistic endeavors or in calendar calculations, an area where some savants shine.
In researching material for the present column, I came across an article by Lawrence Osborne in the July 22, 2003 New York Times headlined “Savant for a Day”. Osborne described his experience during an interview with the aforementioned Allan Snyder in a lab at the University of Sydney in Australia. Osborne agreed to submit himself to TMS. He described the TMS machine as the Medtronic Mag Pro, a machine designed to stimulate or slow down regions of the brain during surgery. Osborne had a series of electrodes placed on his head and attached to something that reminded him of a hair dryer.
Osborne admitted to being rather apprehensive after signing the release form prior to being attached to the Mag Pro. (I can relate to his apprehension, having had an MRI of my own brain some years ago.) When the experiment began, Osborne was asked to draw a cat. He described his first cat as looking more like a stick figure of an insect than a cat. As his brain was subjected to the magnetic pulses, he drew more cats. At the end of the session, even though he had drawn all four cats, he hardly recognized the later ones as his own work. After 10 minutes of TMS, the last cats had tails that were “more vibrant” and “their faces were personable and convincing”. In his words, he had gone from “an incompetent draftsman to a very impressive artist of the feline form”.
In addition to drawing the cats, Snyder asked Osborne to read the following lines:
A bird in the hand
is worth two in the
the bush
Osborne said, “A bird in the hand is worth two in the bush.” Snyder smilingly asked Osborne to repeat this a few times, then turned on the Mag Pro for about five minutes and asked Osborne to read the lines again. With the part of the brain that puts things in context subverted, Osborne for the first time saw the extra “the”.
Such experiments support Snyder’s belief that disabling this particular region of the brain frees one to see just the words themselves without relating them to any particular saying or context. Without the hindrance of trying to make sense of the input to the brain, it seems that normal people can at least show a semblance of savant-like capability.
Not everyone has embraced Snyder’s views. Skeptics say that his experiments on improved artistic abilities after TMS, much like Osborne’s cat drawings, were too subjective to judge. Perhaps to counter such arguments, Snyder and his colleagues are continuing their work, trying to put it on a more quantitative basis. In the September 2006 issue of Discover, there’s a very brief item by J.R. Minkel describing some of this work, a kind of “jelly-bean counting” akin to guessing the number of jelly-beans in a glass jar. I found more details on this recent work on a British Psychological Society (BPS) Research Digest site.
In this work, Snyder and colleagues flashed a varying number of “blobs” (the “jelly-beans”) on a computer screen, the number ranging from 50 to 150. Twelve volunteers were the subjects and they were only given 1.5 seconds looking at the screen to guess the number of blobs. They guessed the number of blobs before and after 15 minutes of TMS. Ten of the 12 volunteers showed significant improvement in estimating the number of blobs after TMS. The BPS site cites two examples. One subject, out of 20 tries before TMS, got none of her guesses within 5 of the correct number. After TMS she got 6 out of 20 within 5. Another volunteer got 3 out 20 within 5 of the correct number before TMS, 10 out of 20 after TMS.
The subjects lost their improved counting ability an hour after the TMS and also showed no improvement when they underwent a sham TMS accompanied by the same noises that went with the real thing but without the magnetic pulses. I’m guessing that the volunteers were happy that their savant-like counting expertise went away. I certainly wouldn’t want to think that the magnetic pulses had disrupted my brain permanently! Hey, I like to think that at least a few of my columns have some degree of context in them. Oh, and if you think some of the stuff I write is a bit weird, I assure you that the MRI of my brain showed it to be perfectly normal. At least that’s what they told me.
Allen F. Bortrum
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